Green Chemistry Articles of Interest to the Pharmaceutical Industry
Marian C. Bryan*, Charlotte Dalton, Alba Díaz-Rodríguez, Jaika Doerfler, Oliver D. Engl, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly, Wei Li, Rachel H. Munday, Jan Pawlas, Paul F. Richardson, William J. Smith III, Alan Steven*, Balaram S. Takale, Jack A. Terrett, Daniel S. Treitler, and Mingshuo Zeng., Org. Process Res. Dev. 2023, 27, 4, 563–570. Publication Date: April 4, 2023. https://doi.org/10.1021/acs.oprd.3c00065

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Melissa A. Ashley, Miles H. Aukland, Marian C. Bryan*, Megan A. Cismesia, Oliver D. Engl, Pascal S. Engl, Álvaro Enriquez Garcia, Alejandro Gimenez Molina, George Karageorgis, Christopher B. Kelly, Alexandre Leclair, Wei Li, Jan Pawlas, Paul F. Richardson, Alan Steven*, Balaram S. Takale, Mingshuo Zeng, and Yongda Zhang., Org. Process Res. Dev. 2023, 27, 11, 1858-1867.
Publication Date: September 13, 2023. https://doi.org/10.1021/acs.oprd.3c00258

A Chemistry in Water Reproducibility Study: Learnings from a Pre-Competitive, Multi-Company Collaboration
Richard Fox, Daniel Bailey, Jennifer Obligacion, Niginia Borlinghaus, Wilfried Braje, Xiaoyong Li, Subha Mukherjee, Adeline Schoen, Timothy Towne, Stella Vukelic., ChemRxiv. 2023.
Publication Date: November 17, 2023. https://doi.org/10.26434/chemrxiv-2023-mgww0

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Bryan, M.C.; Dalton, C.; Díaz-Rodríguez, A.; Doerfler, J.; Engl, O.D.; Ferguson, P.; Gimenez Molina, A.; Han. Z. S.; Hasford, J.; Howell, G.P., et. al. Org. Process Res. Dev. 2022, 26(2), 251-262.
https://doi.org/10.1021/acs.oprd.2c00020

Importance of Green Chemistry and Sustainable Chemistry in the Chemical Laboratory
Colberg, J.; Hii, K. K.; Koenig, S. ACS Sustain. Chem. Eng. 2022, 10(26), 8239-8241.
https://doi.org/10.1021/acssuschemeng.2c03306

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Bryan, M.C.; Dalton, C.; Doerfler, J.; Engl, O.D.; Ferguson, P.; Gimenez Molina, A.; Harawa, V.; Hasford, J.; Howell, G.P., Kelly, C.B.; et. al. Org. Process Res. Dev. 2022, 26(9), 2550-2559.
https://doi.org/10.1021/acs.oprd.2c00274

Green and Sustainable Metrics: Charting the Course for Green-By-Design Small Molecule API Synthesis
Rose, H.B.; Kosjek, B.; Armstrong, B.M.; Robaire, S.A. Curr. Opin. Green Sustain. Chem. 2022, 5, 100324.
https://doi.org/10.1016/j.crgsc.2022.100324 

Streamlined Life Cycle Assessment of Single Use Technologies in Biopharmaceutical Manufacture
Budzinski, K.; Constable, D.; D’Aquila, D.; Smith, P.; Madabhushi, S.R.; Whiting, A.; Costelloe, T.; Collins, M. New. Biotech. 2022, 68, 28-36.
https://doi.org/10.1016/j.nbt.2022.01.002

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Andrews, B. I.;* Firoz, D. A.; Brueggemeier, S. B.; Diorazio L. J; Koenig, S. G.; Kopach, M.; Lee, H.; Olbrich, M. and Watson, A. J. Org. Chem. 2021, 86, 1, 49–61.
https://doi.org/10.1021/acs.joc.0c02291

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Dalton, C.; Diorazio, L. J.; Doerfler, J.; Engl, O. L.; Han, Z. S.; Howell, G. P.; Latham, J.; Li, W.; McLaws, M.; Munday, R. H.; Navarro, A.; Parmentier M.; Pawlas, J.; Richardson, P.; Roiban, G-D.; Steven, A.*; Terrett, J. A.; Treitler, D.S.; and Zeng, M. Org. Process Res. Dev. 2021, 25, 4, 703–712.
https://doi.org/10.1021/acs.oprd.1c0006

Manufacturing Mass Intensity: 15 Years of Process Mass Intensity and Development of the Metric into Plant Cleaning and Beyond
Benison, C.*; Payne, P. Curr. Res. Chem. Green Sustain. Chem.
https://doi.org/10.1016/j.crgsc.2021.100229

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Bryan M. C.*, Dalton, C.; Diorazio, L. J.; Doerfler, J.; Doyle, L. M.; Engl, O. D.; Gimenez Molina, A.; Han, Z. S.; Hosford, J.; Howell, G. P.; Hutchby, M.; Latham, J.; Li, W.; Munday, R. H.; Navarro, A.; Parmentier, M.; Pawlas, J.; Richardson, P. F.; Steven, A.;* Terrett, J. A. and Zeng, M. Org. Process Res. Dev. 2021, 25, 10, 2167–2176.
https://doi.org/10.1021/acs.oprd.1c00352

Making Sustainability Assessment Accessible: Tools Developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable
Diorazio, L. J.; Richardson, R. F.; Sneddon, H.; Moores, A.; Briddell, C. and Martinez, I.* ACS Sustainable Chem. Eng. 2021, 9, 50, 16862–16864.
https://doi.org/10.1021/acssuschemeng.1c07651

Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12
Roschangar, F.*; Li, J.; Zhou, Y.; Aelterman, W.; Borovika, A.; Colberg, J.; Dickson, D.; Gallou, F.; Hayler, J.D.; Koenig, S.G.; Kopach, M.E.; Kosjek, B.; Leahy, D.; O’Brien, E.; Smith, A.G.; Henry, M.; Cook, J. and Sheldon, R. A. ACS Sustainable Chem. Eng. 2021, ASAP. https://pubs.acs.org/doi/10.1021/acssuschemeng.1c01940

Green Chemistry Articles of Interest to the Pharmaceutical Industry; Marie-Gabrielle Braun, Oliver Engl, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Jonathan Latham, Lucie E. Lovelle, Mark McLaws, Paul Richardson, Philipp C. Roosen, Alan Steven, Jack A. Terrett, Timothy White, Jingjun Yin. Org. Process Res. Dev. 2020, 24, 6, 897–908. DOI: 10.1021/acs.oprd.0c00154

Green Chemistry Articles of Interest to the Pharmaceutical Industry; Alba Diaz Rodriguez, Charlotte Dalton, Louis Diorazio, Jaika Doerfler, Oliver D. Engl, Matthew Hickey, Gareth Howell, Marc Hutchby, Jonathan Latham, Wei Li, Rachel Munday, Paul Richardson, Philipp C. Roosen, Alan Steven, Jack A. Terrett, Daniel S. Treitler, Timothy White, and Mingshuo Zeng. Org. Process Res. Dev. 2020, 24, 11, 2394-2406. DOI: 10.1021/acs.oprd.0c00456

A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain; Stefan G. Koenig, Cisco Bee, Alina Borovika, Christiana Briddell, Juan Colberg, Guy R. Humphrey, Michael E. Kopach, Isamir Martinez, Sudhir Nambiar, Scott V. Plummer, Seth D. Ribe, Frank Roschangar, Jeremy P. Scott, Helen F. Sneddon. ACS Sustainable Chem. Eng. 2019, 7, 16937−16951. DOI: 10.1021/acssuschemeng.9b02842

Bringing Macrolactamization Full Circle: Self-Cleaving Head-to-Tail Macrocyclization of Unprotected Peptides via Mild N-Acyl Urea Activation; Christine A. Arbour, Kayla J. Belavek, Rooha Tariq, Subha Mukherjee, Janine K. Tom, Albert Isidro-Llobet, Michael E. Kopach, Jennifer L. Stockdill.
J. Org. Chem. 2019, 84(2), 1035-1041. DOI: 10.1021/acs.joc.8b02418

Green Chemistry Articles of Interest to the Pharmaceutical Industry, Issue 23; Marie-Gabrielle Braun, John Hayler, Andrew Parsons, Alba Díaz-Rodríguez, Matthew Hickey, Paul Richardson, Louis Diorazio, Lucie Lovelle, Doru Roiban, Kenneth Fraunhoffer, Mark McLaws, Alan Steven. Org. Process Res. Dev. 2019, 23, 6, 1118-1133. DOI: 10.1021/acs.oprd.9b00158

Green Chemistry Articles of Interest to the Pharmaceutical Industry, Issue 24; Marie-Gabrielle Braun,  John Hayler, Andrew Parsons, Alan Steven, Jonathan Latham, Matthew Hickey, Paul Richardson, Jack A. Terrett, Louis Diorazio, Lucie Lovelle, Doru Roiban, Timothy White, Kenneth Fraunhoffer, Mark McLaws, Philipp C. Roosen, Jingjun Yin. Org. Process Res. Dev. 2019, 23, 2287-2301. DOI: 10.1021/acs.oprd.9b00450

Introduction of a process mass intensity metric for biologics; Kristi Budzinski, Megan Blewis, Philip Dahlin, Daniel D’Aquila, Julia Esparza, Jack Gavin, Sa V. Ho, Clarice Hutchens, David Kahn, Stefan G. Koenig, Robert Kottmeier, Jeff Millard, Matt Snyder, Brad Stanard, Lixin Sun. New Biotechnology. 2019, 49, 37-42. DOI: 10.1016/j.nbt.2018.07.005.

Making the move towards modernized greener separations: introduction of the analytical method greenness score (AMGS) calculator; Michael B. Hicks, William Farrell, Christine Aurigemma, Laurent Lehmann, Lauren Weisel, Kelly Nadeau, Heewon Lee, Carol Moraff, Mengling Wong, Yun Huangh, Paul Ferguson. Green Chem., 2019 ,21, 1816-1826. DOI: 10.1039/C8GC03875A

Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production; Albert Isidro-Llobet, Martin N. Kenworthy, Subha Mukherjee, Michael E. Kopach, Katarzyna Wegner, Fabrice Gallou, Austin G. Smith, Frank Rrochangar. J. Org. Chem. 2019, 84(8), 4615-4628. DOI: 10.1021/acs.joc.8b03001

The PMI Predictor – a Web App Enabling Green-by-Design Chemical Synthesis; A. Borovika, J. Albrecht, J. Li, A. S. Wells, C. Briddell, B. R. Dillion, L. J. Diorazio, J. R. Gage, F. Gallou, S. G. Koenig, M. E. Kopach, D. K. Leahy, I. Martinez, M. Olbrich, J. L. Piper, F. Roschangar, E. Sherer, M. D. Eastgate. ChemRxiv, Preprint 1/16/2019